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. 2015 Dec 23;68(1):120–130. doi: 10.1080/01635581.2016.1115094

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

© 2016 Anupam Bishayee, Animesh Mandal, Piyali Bhattacharyya, and Deepak Bhatia

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 2. — Chemoprevention of 7,12-dimethylbenz(a)anthracene (DMBA)-initiated rat mammary tumorigenesis by pomegranate. Effects of pomegranate emulsion (PE) on the size of mammary tumors (A–D), intratumor histopathological profiles (E–H), cell proliferation (I–L), apoptosis (M–P), Bax (Q–T), and Bcl2 (U–X) protein expression. The rats were treated with oral PE 2 wk prior to and 16 wk following DMBA administration. All animals were sacrificed 16 wk following DMBA exposure. The mammary tumors were subjected to morphological observation as well histopathological (H&E) and immunohistochemical analysis using anti-PCNA, anti-Bax, and anti-Bcl2 antibodies. Apoptosis was detected by DNA fragmentation assay. Magnification: 100× for tumor and H&E and 200× for PCNA, apoptosis, Bax, and Bcl2.