Table 1.
Effect of oral PE administration on DMBA-induced mammary tumorigenesis in Sprague-Dawley rats.
| Treatment groups | No. of rats with tumors/total rats | Tumor incidence (%) | Total tumor burden (g) | Inhibition (%) | Average tumor weight (g) | Inhibition (%) |
|---|---|---|---|---|---|---|
| Group B: DMBA | 9/11 | 82 | 89.0 | — | 14.8±4.8 | — |
| Group C: PE (0.2 g/kg) + DMBA | 5/8 | 62 | 21.7 | 76 | 2.0±0.3 | 86 |
| Group D: PE (1 g/kg) + DMBA | 5/8 | 62 | 16.8 | 81 | 1.4±0.3 | 90 |
| Group E: PE (5 g/kg) + DMBA | 2/7 | 28 | 5.9 | 93 | 1.5±0.9 | 90 |
Rats from normal (Group A, n = 12) and PE (5 g/kg) control group (Group F, n = 5) did not show any visible mammary tumor. PE = pomegranate emulsion; DMBA = 7,12-dimethylbenz(a)anthracene.
*
P < 0.05 compared with DMBA (Group B) by Fisher's exact probability test.
**
P < 0.001 compared with DMBA (Group B) by analysis of variance followed by Holm-Sidak test.