. 2015 Aug 7;2:2333794X15599649. doi: 10.1177/2333794X15599649

Table 3.

Summary of Clinical Presentations and Relevant Investigation Findings in Previously Reported Cases of Kawasaki Disease With Myositis.

Title	Author, Journal, Year	Clinical Presentation	Relevant Investigation Findings	Conclusion
Myositis in Kawasaki disease⁸	Gama et al, Pediatr Neurol, 1990	8-Year-old boy, previously well, presented with clinical features of KD, diffused peripheral weakness, and respiratory failure	• CK: 1509 to 2657 IU	Myositis is one of several neurological complications encountered in KD. The degree of CK elevation may be useful in predicting the severity of myopathy.
			• EMG: myopathic pattern
			• Muscle biopsy: atrophy and degeneration
A case of polymyositis associated with Kawasaki disease⁹	Sugie et al, Brain Dev, 1985	3-Year-old boy, previously well, was diagnosed with KD, and developed painful proximal muscle weakness in all extremities	• CK: 152 IU	Polymyositis might be a complication of KD. Proximal muscle weakness suggests inflammatory myopathy, even if serum CK was not significantly elevated.
			• EMG: myopathic change
			• Muscle biopsy: mild architecture distortion, fiber atrophy, inflammatory cell infiltrates
Myositis with Kawasaki’s disease¹⁰	Koutras, Am J Dis Child, 1982	18-Month-old girl, previously well, presented with clinical features of KD and severe proximal muscle weakness and tenderness with dysphonia and dysphagia	• CK: 72 U/L	Clinical presentation suggests a coexistence of KD and myositis.
Neuromuscular and immunochemical abnormalities in an adult man with Kawasaki disease¹¹	Hicks et al, Ann Intern Med, 1982	A 40-year-old man presented with primary features of KD and distal motor and sensory neuropathy	• Elevated CK	There is a possibility that clinical features and complications of KD are mediated by immune complex deposition in vessels and tissues.
			• Abnormal EMG
			• Muscle biopsy: myonecrosis, immunoglobulin deposit, distorted architecture
Orbital myositis due to Kawasaki’s disease¹²	Lin et al, Pediatr Radiol, 1999	An 8-month-old boy, previously well, was diagnosed with and treated for KD. He developed unilateral edema and erythema of the upper eye lid with impaired extra-ocular movement 18 days after apparent remission of KD.	• CT orbit: soft tissue swelling of eyelid with thickened orbicularis muscle	Orbital myositis can possibly be a complication of KD
Orbital myositis due to Kawasaki’s disease¹²	Lin et al, Pediatr Radiol, 1999		• Histology: pan-arteritis and myositis	Orbital myositis can possibly be a complication of KD

Abbreviations: KD, Kawasaki disease; CK, creatine kinase; EMG, electromyography; CT, computed tomography.