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. 2016 Feb 25;1(2):e85633. doi: 10.1172/jci.insight.85633

Figure 3. IgG-eluted immune proteome from the synovial fluid of patients with juvenile idiopathic arthritis and controls.

Figure 3

Hierarchical cluster analysis (HCA) of proteins eluted from the IgG purified from the synovial fluid of patients with juvenile idiopathic arthritis (JIA) and controls (data were compiled from 3 separate proteomic analyses). Quantitative data sets were generated for each protein entry in Scaffold 4 using the log of the normalized spectral abundance factor [ln(NSAF)] values [average of 3 experiments for the ln(NSAF)]. The Ward’s dual-clustering method followed by the t test was performed for comparison of 2 controls and 7 JIA patients. The HCA depicts proteins with at least a 1.5-fold difference in expression between the JIA and the control groups, with statistical significance corresponding to a FDR value < 0.7 [green corresponds to the lowest ln(NSAF), while red corresponds to the highest ln(NSAF)] (proteomic data used to compile the heat map are reported in Supplemental Table 5).