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. 2016 Feb 25;1(2):e85633. doi: 10.1172/jci.insight.85633

Figure 4. Transthyretin and anti-transthyretin antibodies in the synovial fluid and sera of juvenile idiopathic arthritis patients and controls.

Figure 4

(A) Quantification of transthyretin (TTR) autoantibodies, as detected by ELISA, present in the synovial fluid from patients with juvenile idiopathic arthritis (JIA) and controls (data were compiled from 3 separate ELISAs, with each patient’s samples run in quadruplicate). Data were analyzed by 1-way ANOVA and Tukey test. (B) Quantification of TTR autoantibodies, as detected by ELISA, present in the sera of patients with JIA and controls (data were compiled from 3 separate ELISAs, with each patient’s samples run in quadruplicate). Data were analyzed by 1-way ANOVA and Tukey test. (C and D) Amount of TTR present in the synovial fluid and sera from patients with JIA and controls (data were compiled from 3 separate ELISAs, with each patient’s samples run in quadruplicate) Data were analyzed by 1-way ANOVA and Tukey test. (E) Correlation between TTR protein and anti-TTR antibodies (Spearman r = 0.72, ****P < 0.001). The patient ID for each circle is reported in Supplemental Figure 4. Mean ± SD. *P < 0.05; **P < 0.005; ****P < 0.001.