Table 1.
Human chemokine receptors and their cellular expression. Table showing the accepted cellular/tissue distribution of chemokine receptors and their ligands. Abbreviations: B, B-lymphocyte; Bro, Bronchial epithelial cells; Bs, basophil; DC, dendritic cell; Eo, eosinophil; Ker, keratinocytes; Mc, mast cell; Mo, monocyte; MSC, Mesenchymal Stem cell, NK, natural killer cell; No, neutrophil; NT, neuronal tissue; LEC, lymphatic endothelial cell; P, platelets; RBC, red blood cell; SLO, secondary lymphoid organ; Syn, Syncytiotrophoblast; T, T-lymphocytes; VEC, vascular endothelial cell (adapted from Pease, 2011).
| Chemokine receptor | Chemokine ligands | Cellular expression | Chemokine receptor | Chemokine ligands | Cellular expression |
|---|---|---|---|---|---|
| CCR1 | CCL3, CCL4, CCL5, CCL7, CCL8, CCL13, CCL14, CCL15, CCL16, CCL23 | Mo, DC, Eo, Bs, T, PMN, NK | CXCR1 | CXCL5, CXCL6, CXCL8 | No, Mo |
| CCR2 | CCL2, CCL5, CCL7, CCL8, CCL13, CCL16 | Mo, DC, T, Bs | CXCR2 | CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, CXCL8 | No, Mo |
| CCR3 | CCL4, CCL5, CCL7, CCL11, CCL13, CCL15, CCL24, CCL26, CCL28 | Eo, T, Bs, Mc | CXCR3 | CXCL4, CXCL4L1, CXCL9, CXCL10, CXCL11, | T, B |
| CCR4 | CCL17, CCL22 | T, MC, Bro, NK, P | CXCR4 | CXCL12 | T, B, DC, Mo |
| CCR5 | CCL3, CCL4, CCL5, CCL7, CCL14, CCL15 | Mo, DC, T | CXCR5 | CXCL13 | T, B |
| CCR6 | CCL20 | DC, T | CXCR6 | CXCL16 | T |
| CCR7 | CCL19, CCL21 | DC, T, B, NK | |||
| CCR8 | CCL1, CCL18 | Mo, T, NK | XCR1 | XCL1, XCL2 | T, NK |
| CCR9 | CCL25 | T | |||
| CCR10 | CCL27, CCL28 | T | CX3CR1 | CX3CL1 | T, NK, DC, Mo |
| ACKR1 (DARC) | CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17,CXCL5, CXCL6,CXCL11 | RBC, VEC | ACKR2 (D6) | CCL1,CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CCL22 | LEC, Syn |
| ACKR3 (CXCR7) | CXCL11, CXCL12 | B, MSC, NT | ACKR4 (CCRL1) | CCL19, CCL21, CCL25 | Ker, SLO |