Table 5. Decreased immune functions in super-shedders identified by the DE genes using IPA.
| Associated immune cells | Functions Annotation | z-score | Associated molecules |
|---|---|---|---|
| cell movement of T lymphocytes | -2.4 | CCL19, CCL21, CCR7, CD69, CXCL13, IL2RA, LTB, SPP1 | |
| T cell homeostasis | -2.4 | CD79A, IL2RA, LEF1, LTB, RHOH, SH2D1A, SPP1, TCF7, THEMIS | |
| T-cells | T cell development | -2.4 | CD79A, IL2RA, LEF1, LTB, RHOH, SH2D1A, SPP1, TCF7, THEMIS |
| quantity of T lymphocytes | -2.3 | CCL19, CCL21, CCR7, CD79A, IL2RA, LTB, POU2AF1, RHOH, SASH3, SH2D1A, SIT1, THEMIS | |
| quantity of CD4+ T-lymphocytes | -2.2 | CD69, RHOH, SH2D1A, SIT1, THEMIS | |
| quantity of regulatory T lymphocytes | -2.2 | CCL19, CCL21, IL2RA, LTB, THEMIS | |
| quantity of lymphocytes | -2.6 | CCL19, CCL21, CCR7, CD19, CD22, CD79A, CD79B, CXCL13, IL2RA, KLHL6, LTB, MS4A1, POU2AF1, RHOH, SASH3, SH2D1A, SIT1, THEMIS | |
| development of lymphocytes | -2.5 | CD19, CD79A, GIMAP5, IL2RA, LEF1, LTB, RHOH, SH2D1A, SPP1, TCF7, THEMIS | |
| binding of lymphocytes | -2.2 | CCL19, CCL21, CD22, CXCL13, SH2D1A | |
| T-, B-cell | infiltration by lymphocytes | -2.2 | CCL19, CCL21, CCR7, IL2RA, LTB |
| activation of lymphocytes | -2.0 | CD19, CD69, PLA2G2A, POU2AF1, S100A9, SASH3, SH2D1A, SPP1 | |
| maturation of lymphocytes | -2.0 | CD19, LEF1, RHOH, TCF7 | |
| cell viability of lymphocytes | -2.4 | CD19, CD22, CD79A, GIMAP5, LEF1, TCF7 | |
| Lymphocyte migration | -2.1 | CCL19, CCL21, CCR7, CD69, CXCL13, IL2RA, LTB, SH2D1A, SPP1 | |
| Phagocyte, macrophage, dendritic, neutrophils | cell movement of phagocytes | -2.7 | CCL19, CCL21, CCR7, CXCL13, LTB, S100A8, S100A9, SPP1 |
| Neutrophils | chemotaxis of neutrophils | -2.6 | CCL19, CCL21, CCR7, CD69, S100A8, S100A9, SPP1 |
| Dendritic cells | migration of dendritic cells | -2.2 | CCL19, CCL21, CCR7, CXCL13, SPP1 |
| NK cells* | activation of natural killer cells | -2.0 | CD69, S100A9, SH2D1A, SPP1 |
* NK cells: natural killer cells.