Table 2. Difference in restricted mean survival time and ICER according to the survival analysis method.

Survival methods		Difference in restricted mean survival time (in month) [95% CI]	Mean ICER (cost per life year gained) [95% CI]
Approach 1	Peto-quintiles	1.7 [0.4–3.1]	€ 34,934 [12,506–98,066]
	Peto-year	1.8 [0.5–3.0]	€ 33,387 [13,512–75,753]
	Stewart-Parmar	2.1 [0.6–3.5]	€ 29,017 [11,822–68,206]
	Naive Kaplan-Meier	2.2 [0.6–3.7]	€ 26,848 [11,152–68,297]
	Peto-month	2.3 [0.7–3.9]	€ 28,022 [10,563–61,608]
Approach 2	Pooled Kaplan-Meier	2.3 [0.7–3.8]	€ 25,527 [10,355–66,289]
	Pooled Exponential	2.5 [0.7–4.2]	€ 24,299 [9,584–59,119]

CI: confidence interval; ICER: Incremental Cost-Effectiveness Ratio; rmstD: difference in restricted mean survival time