Table 4. PPV and sensitivity for the algorithms.
| Algorithm | N events identified in the CPRD | N events confirmed by reference standard | PPV (95% CI) | N events identified in the CPRD in last year | N extra events identified by other algorithms or GPs in last year | Sensitivity (95% CI) |
|---|---|---|---|---|---|---|
| 1.OCS prescription | 1152 | 841 | 73.0 (69.5–76.5) | 164 | 379 | 30.2(25.8–34.6) |
| 2.Antibiotic prescription | 5840 | 3559 | 60.9 (59.0–62.9) | 386 | 157 | 71.1 (66.8–75.4) |
| 3.OCS and antibiotic prescription | 823 | 653 | 79.3 (75.8–82.9) | 133 | 410 | 24.5 (20.4–28.6) |
| 4. Symptom definition | 142 | 92 | 64.8 (56.2–73.3) | 14 | 529 | 2.6 (1.1–4.0) |
| 5. Symptom definition and OCS prescription | 88 | 79 | 89.8 (82.9–96.7) | 12 | 531 | 2.2 (0.9–3.6) |
| 6. Symptom definition and antibiotic prescription | 57 | 53 | 93.0 (85.6–100.0) | 10 | 533 | 1.8 (0.6–3.1) |
| 7. Symptom definition and OCS & antibiotic prescription | 48 | 47 | 97.9 (94.5–100.0) | 9 | 534 | 1.7 (0.5–2.9) |
| 8. LRTI code | 1745 | 1389 | 79.6 (76.9–82.3) | 125 | 418 | 23.0 (19.2–26.8) |
| 9. LRTI code and OCS prescription | 1558 | 1268 | 81.4 (78.7–84.1) | 108 | 435 | 19.9 (16.3–23.5) |
| 10. LRTI code and antibiotic prescription | 393 | 347 | 88.3 (84.4–92.2) | 65 | 478 | 12.0 (9.3–14.7) |
| 11. LRTI code and OCS & antibiotic prescription | 371 | 327 | 88.1 (84.1–92.1) | 62 | 481 | 11.4 (8.8–14.0) |
| 12. AECOPD code | 885 | 850 | 96.0 (94.5–97.6) | 136 | 407 | 25.1 (20.9–29.2) |
| 13. AECOPD code and OCS prescription | 638 | 618 | 96.9 (95.4–98.3) | 99 | 444 | 18.2 (14.6–21.8) |
| 14. AECOPD code and antibiotic prescription | 423 | 408 | 96.5 (94.5–98.4) | 95 | 448 | 17.5 (13.8–21.2) |
| 15. AECOPD code and OCS & antibiotic prescription | 377 | 365 | 96.8 (95.0–98.6) | 87 | 456 | 16.0 (12.6–19.5) |
Antibiotics = selected antibiotics with clinical application in management of AECOPD
OCS = oral corticosteroids specific to AECOPD management