. 2016 Mar 9;11(3):e0150858. doi: 10.1371/journal.pone.0150858

Table 2. Most extreme differentially expressed genes between BCG-challenged and Control mice within microglia (|log₂(fold change)| > 3, FDR-adjusted P-value < 2.0 x 10⁻³) and macrophages (|log₂(fold change)| > 6, FDR-adjusted P-value < 3.0 x 10⁻⁴) and supporting literature review.

Gene Symbol	Gene name NCBI	Log₂(BCG/ Control)	References
Microglia; BCG-challenged vs Control mice
Saa3	serum amyloid A 3	5.90	[37–40]
Cadm3	cell adhesion molecule 3	5.14	[37]
Steap4	STEAP family member 4	4.89	[41,42]
Sele	selectin E	4.80	[43,44]
Cxcr1	chemokine (C-X-C Motif) receptor 1	4.03	[39,45,46]
Ifitm1	interferon induced transmembrane protein 1	3.72	[38,39,44,47]
Irg1	immunoresponsive 1 homolog: involved in the inhibition of the inflammatory response.	3.66	[46,48,49]
Lrg1	leucine-rich alpha-2-glycoprotein 1	3.57	[40,50]
Prok2	prokineticin 2	3.48	[50]
Cfb	complement factor B	3.39	[38]
Slfn4	schlafen 4	3.33	[40,48]
Nxpe5	neurexophilin and PC-esterase domain family, member 5	3.29	[51]
Ly6i	lymphocyte antigen 6 complex, locus I	3.29	[38,49]
Oas3	2'-5'-oligoadenylate synthetase 3, 100kDa	3.27	[38,52]
Ifi205	interferon activated gene 205	3.15	[38,53]
Stfa1	stefin A1	3.12	[54]
Plac8	placenta-specific 8	3.09	[38,44]
Macrophages; BCG-challenged vs Control mice
S100a9	S100 calcium binding protein A9 (calgranulin B)	10.11	[55]
Mrgpra2a	MAS-related GPR, member A2A	10.10
Ly6i	lymphocyte antigen 6 complex, locus I	9.42
Asprv1	aspartic peptidase, retroviral-like 1	9.15
Ly6c2	lymphocyte antigen 6 complex, locus C2	7.92	[56]
Nos2	nitric oxide synthase 2, inducible	7.69	[57]
Il1f9	interleukin 1 family, member 9	7.66	[58]
Ccl8	chemokine (C-C motif) ligand 8	7.45	[41]
2010002M12Rik	interferon induced protein with tetratricopeptide repeats 1B like 2	7.32
Spon1	spondin 1, (f-spondin) extracellular matrix protein	7.23	[59]
S100a8	S100 calcium binding protein A8 (calgranulin A)	7.15	[60]
Cxcr2	chemokine (C-X-C motif) receptor 2	7.02
Ifng	interferon gamma	6.45	[61]
Cxcl9	chemokine (C-X-C motif) ligand 9	6.40
Gpr141	G protein-coupled receptor 141	6.15
2010005H15Rik	RIKEN cDNA 2010005H15 gene	6.14
Iigp1	interferon inducible GTPase 1	6.08

Table 2. Most extreme differentially expressed genes between BCG-challenged and Control mice within microglia (|log2(fold change)| > 3, FDR-adjusted P-value < 2.0 x 10−3) and macrophages (|log2(fold change)| > 6, FDR-adjusted P-value < 3.0 x 10−4) and supporting literature review.

Table 2. Most extreme differentially expressed genes between BCG-challenged and Control mice within microglia (|log₂(fold change)| > 3, FDR-adjusted P-value < 2.0 x 10⁻³) and macrophages (|log₂(fold change)| > 6, FDR-adjusted P-value < 3.0 x 10⁻⁴) and supporting literature review.