Table 3. Most significant clusters (DAVID Enrichment Score ES > 4) of enriched Gene Ontology (GO) biological processes (BP) and molecular functions (MF) among the genes differentially abundant between BCG-challenged and Control mice within cell type.
| Cell type and cluster1 | Terms2 | ES |
|---|---|---|
| Microglia | ||
| BP | ~defense response ~inflammatory response ~response to wounding | 12.96 |
| BP | ~chemotaxis ~taxis ~locomotory behavior | 5.63 |
| MF | ~carbohydrate binding ~polysaccharide binding ~pattern binding | 5.12 |
| MF | ~peptidase inhibitor activity ~endopeptidase inhibitor activity ~enzyme inhibitor activity | 4.88 |
| BP | ~immune effector process ~adaptive immune response ~adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 4.75 |
| BP | ~cell adhesion ~biological adhesion ~cell-cell adhesion | 4.37 |
| Macrophages | ||
| BP | ~defense response ~response to wounding ~inflammatory response | 13.32 |
| MF | ~carbohydrate binding ~polysaccharide binding ~pattern binding | 8.18 |
| BP,MF | ~chemotaxis ~taxis ~chemokine activity | 7.79 |
| BP | ~cell activation ~leukocyte activation ~lymphocyte activation | 6.17 |
| BP | ~vasculature development ~blood vessel development ~blood vessel morphogenesis | 6.12 |
| BP | ~regulation of cytokine production ~positive regulation of cytokine production ~positive regulation of multicellular organismal process | 5.97 |
| BP | ~positive regulation of immune system process ~positive regulation of response to stimulus ~positive regulation of immune response | 5.86 |
| BP | ~immune effector process ~leukocyte mediated immunity ~adaptive immune response | 5.02 |
| BP | ~apoptosis ~programmed cell death ~cell death | 4.77 |
| BP | ~regulation of phosphorylation ~regulation of phosphorus metabolic process ~regulation of phosphate metabolic process | 4.34 |
| BP,MF | ~GTPase regulator activity ~nucleoside-triphosphatase regulator activity ~GTPase activator activity | 4.20 |
| BP | ~positive regulation of immune system process ~regulation of leukocyte activation ~regulation of cell activation | 4.01 |
1 Each row corresponds to a cluster of Functional Annotation Tool (FAT) GO categories.
2 The three GO terms exhibiting most significant enrichment P-value in each cluster are listed, separated by “~”. Additional information in each cluster is provided in S2 Table.