Table 5. Gene Set Enrichment Analysis (GSEA) categories enriched among transcript isoforms over-expressed (FDR-adjusted P-value < 1.5 x 10−2 > 10 transcript isoforms) and under- expressed (FDR-adjusted P-value < 5 x 10−4 > 10 transcript isoforms) in BCG-challenged relative to Control mice in macrophages.
| Categories | NG1 | P-value | FDR2 |
|---|---|---|---|
| Over-expressed in BCG-challenged relative to Control mice | |||
| KEGG ECM receptor interaction | 45 | <0.1E-05 | 9.96E-04 |
| Defense response | 144 | <0.1E-05 | 5.88E-03 |
| Inflammatory response | 73 | <0.1E-05 | 1.28E-02 |
| Serine type peptidase activity | 18 | <0.1E-05 | 1.31E-02 |
| Serine hydrolase activity | 19 | <0.1E-05 | 1.32E-02 |
| KEGG proteasome | 43 | <0.1E-05 | 1.48E-02 |
| Under-expressed in BCG-challenged relative to Control mice | |||
| KEGG ribosome | 78 | <0.1E-05 | <0.1E-05 |
| Structural constituent of ribosome | 75 | <0.1E-05 | <0.1E-05 |
| Gated channel activity | 27 | <0.1E-05 | <0.1E-05 |
| Cation channel activity | 29 | <0.1E-05 | 2.39E-04 |
1 NG: number of genes.
2 FDR: adjusted P-value.