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. 2016 Mar 9;11(3):e0150858. doi: 10.1371/journal.pone.0150858

Table 6. Most extreme differentially expressed genes (FDR-adjusted P-value < 2.0 x 10−4) between microglia and macrophages in BCG-challenged mice and supporting literature review.

Gene Symbol NCBI Gene Name Log2(Macrophages/Microglia) Reference
Col8a1 collagen, type VIII, alpha 1 -13.70 [103]
Kcne2 potassium voltage-gated channel, Isk-related subfamily, gene 2 -13.63 [104]
Slc38a5 solute carrier family 38, member 5 -11.61
Lrrc3 predicted gene 884 -11.49 [105]
Nav3 neuron navigator 3 -11.27 [106]
Gm694 predicted gene 694 -11.07
Capn3 calpain 3 -11.06 [107]
Gpr34 G protein-coupled receptor 34 -10.49 [39,105,106]
Lrrn1 leucine rich repeat protein 1, neuronal -10.30 [108]
Wwox WW domain-containing oxidoreductase -10.24
Vstm4 V-set and transmembrane domain containing 4 -10.07
Ecscr endothelial cell surface expressed chemotaxis and apoptosis regulator -9.95 [39]
Cenpf centromere protein F -9.93
Gm10790 predicted gene 10790 -9.93
Tspan7 tetraspanin 7 -9.79 [105]
Epn3 epsin 3 -9.76
Tmem100 transmembrane protein 100 -9.73 [105]
Leprel1 prolyl 3-hydroxylase 2 -9.72 [105]
Ebf3 early B cell factor 3 -9.71 [105]
Rnu11 U11 small nuclear RNA -9.65
Wdr52 cilia and flagella associated protein 44 -9.60
Olfml3 olfactomedin-like 3 -9.60 [39,105]
Trpm3 transient receptor potential cation channel, subfamily M, member 3 -9.58
Fat3 FAT tumor suppressor homolog 3 (Drosophila) -9.56
Adcy2 adenylate cyclase 2 -9.52
Kcnj13 potassium inwardly-rectifying channel, subfamily J, member 13 -9.48
Gpr56 adhesion G protein-coupled receptor G1 -9.46 [39,105]
Sema4g sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G -9.45
Ecm1 extracellular matrix protein 1 6.89 [39]
F10 coagulation factor X 6.90
Spib Spi-B transcription factor (Spi-1/PU.1 related) 6.90
Cxcr5 chemokine (C-X-C motif) receptor 5 6.98 [39]
Cxcl3 chemokine (C-X-C motif) ligand 3 7.07 [39]
Flrt3 fibronectin leucine rich transmembrane protein 3 7.14 [39]
Selplg P-selectin glycoprotein ligand 1 7.16 [39]
Cd19 CD19 antigen 7.17 [39]
Retnla resistin like alpha 7.25 [39]
Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 7.42
Cd79a CD79A antigen (immunoglobulin-associated alpha) 7.49
Mcoln2 mucolipin 2 7.54
Vsig4 V-set and immunoglobulin domain containing 4 7.55
Fcrla Fc receptor-like A 7.64
Ms4a1 membrane-spanning 4-domains, subfamily A, member 1 7.68
Cd163l1 CD163 molecule-like 1 7.76
Gjb5 gap junction protein, beta 5 7.86
Vmn2r24 vomeronasal 2, receptor 24 7.86
Scn4a sodium channel, voltage-gated, type IV, alpha 7.88
Il9r interleukin 9 receptor 7.95
Blk B lymphoid kinase 8.01
F7 coagulation factor VII 8.11 [40]
Fcrl5 Fc receptor-like 5 8.14
Serpinb2 serine (or cysteine) peptidase inhibitor, clade B, member 2 8.21 [39]
Pou2af1 POU domain, class 2, associating factor 1 8.44
Ptges prostaglandin E synthase 8.66 [109]
Cxcl13 chemokine (C-X-C motif) ligand 13 9.30 [39]
Nos2 nitric oxide synthase 2, inducible 9.33 [79]
Cd5l CD5 antigen-like 9.34 [39]
Arg1 arginase, liver 10.05 [110]