Table 7. Most significant clusters (DAVID Enrichment Score ES > 4) of enriched Gene Ontology (GO) biological processes (BP) and molecular functions (MF) among the transcript isoforms differentially abundant between microglia and macrophages from BCG-challenged mice.
| GO cluster1 | Terms2 | ES |
|---|---|---|
| BP | ~response to wounding~inflammatory response~defense response | 8.72 |
| BP | ~regulation of cell activation~regulation of leukocyte activation~positive regulation of immune system process | 6.72 |
| BP | ~cell migration~localization of cell~cell motility | 6.55 |
| BP | ~regulation of cytokine production~regulation of cytokine biosynthetic process~positive regulation of cytokine biosynthetic process | 6.44 |
| MF,BP | ~purine nucleotide binding~ribonucleotide binding~purine ribonucleotide binding | 6.14 |
| MF,BP | ~taxis~chemotaxis~chemokine activity | 6.04 |
| BP | ~cell death~death~programmed cell death | 5.92 |
| BP | ~regulation of apoptosis~regulation of programmed cell death~regulation of cell death | 5.53 |
| BP | ~regulation of cell activation~regulation of leukocyte activation~regulation of lymphocyte activation | 5.26 |
| BP | ~vasculature development~blood vessel development~blood vessel morphogenesis | 4.59 |
| BP | ~hemopoietic or lymphoid organ development~immune system development~hemopoiesis | 4.59 |
| BP | ~regulation of cytokine production~regulation of interferon-gamma production~positive regulation of cytokine production | 4.26 |
| MF | ~GTP binding~guanyl ribonucleotide binding~guanyl nucleotide binding | 4.07 |
1 Each row corresponds to a cluster of Functional Annotation Tool (FAT) GO categories.
2 The three GO terms exhibiting most significant enrichment P-value in each cluster are listed, separated by “~”. Additional information in each cluster is provided in S6 Table