Table 8. Gene Set Enrichment Analysis (GSEA) categories enriched (FDR-adjusted P-value < 0.01, > 10 transcript isoforms) among transcript isoforms under-expressed in microglia relative to peripheral macrophages in BCG-challenged mice.
Category | NG1 | P-value | FDR2 |
---|---|---|---|
Adaptive immune response | 21 | <0.1E-05 | <0.1E-05 |
Adaptive immune response | 20 | <0.1E-05 | <0.1E-05 |
Positive regulation of immune response | 20 | <0.1E-05 | <0.1E-05 |
Regulation of immune response | 22 | <0.1E-05 | <0.1E-05 |
Regulation of immune system process | 46 | <0.1E-05 | 1.05E-03 |
Chemokine receptor binding | 28 | <0.1E-05 | 1.18E-03 |
Positive regulation of immune system process | 37 | <0.1E-05 | 1.34E-03 |
Positive regulation of response to stimulus | 27 | <0.1E-05 | 1.57E-03 |
KEGG primary immunodeficiency | 30 | <0.1E-05 | 1.88E-03 |
KEGG ribosome | 81 | <0.1E-05 | 1.90E-03 |
Regulation of lymphocyte activation | 28 | <0.1E-05 | 2.07E-03 |
Cellular defense response | 38 | <0.1E-05 | 2.28E-03 |
Lymphocyte activation | 47 | <0.1E-05 | 3.78E-03 |
G protein coupled receptor binding | 35 | <0.1E-05 | 4.34E-03 |
Chemokine activity | 27 | <0.1E-05 | 4.62E-03 |
Positive regulation of multicellular organismal process | 47 | <0.1E-05 | 4.63E-03 |
Cytokine activity | 61 | <0.1E-05 | 6.65E-03 |
B cell activation | 18 | <0.1E-05 | 7.59E-03 |
Locomotory behavior | 61 | <0.1E-05 | 8.08E-03 |
Leukocyte activation | 51 | <0.1E-05 | 8.95E-03 |
KEGG hematopoietic cell lineage | 52 | <0.1E-05 | 9.40E-03 |
1 NG: number of genes.
2 FDR: adjusted P-value.