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. 2016 Mar 9;11(3):e0151118. doi: 10.1371/journal.pone.0151118

Table 4. Selected genes differentially expressed in cashmere goat skin during the HF cytodifferentiation and maturation.

Class Gene Gene Name log2 Fold Change P value FDR
E120/E60 NB/E60 E120/E60 NB/E60 E120/E60 NB/E60
Hair follicle and transcriptional regulator genes
CST6 cystatin E/M, mRNA 7.24 7.71 0.0003 0.0029 0.0212 0.0304
DSG4 desmoglein 4 10.48 10.53 0.0000 0.0027 0.0109 0.0294
FOXN1 forkhead box N1 - 7.10 - 0.0037 - 0.0341
LHX2 LIM homeobox 2 7.82 7.53 0.0012 0.0006 0.0310 0.0159
HOXC13 homebox C13 9.68 9.39 0.0036 0.0007 0.0451 0.0170
PRR9 proline rich 9 9.66 10.02 0.0003 0.0008 0.0202 0.0175
VSIG8 V-set and immunoglobulin domain-containing 8 - 8.20 - 0.0004 - 0.0137
PADI3 peptidylarginine deiminase, type III 9.94 9.75 0.0043 0.0011 0.0484 0.0199
Wnt related
SFRP5 secreted frizzled-related protein 5 4.35 4.57 0.0000 0.0023 0.0112 0.0273
CHP2 calcineurin-like EF-hand protein 2 1.53 - 0.0045 - 0.0494 -
CTNNB1 catenin cadherin-associated protein beta 1 transcript variant X3 - 1.11 - 0.0044 - 0.0367
FZD10 frizzled family receptor 10 - 1.58 - 0.0042 - 0.0362
CTNNBIP1 catenin, beta interacting protein 1, transcript variant X1 2.26 2.46 0.0006 0.0055 0.0242 0.0413
WNT11 wingless-type MMTV integration site family, member 11 - 1.31 - 0.0010 - 0.0193
TCF7 transcription factor 7 (T-cell specific, HMG-box), transcript variant X4 1.46 - 0.0000 - 0.0045 -
WIF1 WNT inhibitory factor 1, transcript variant X1 5.13 - 0.0023 - 0.0385 -
WNT10A wingless-type MMTV integration site family, member 10A - 1.79 - 0.0029 - 0.0301
FZD5 frizzled family receptor 5 3.20 - 0.0016 - 0.0335 -
TGF-beta/BMP
SMAD6 SMAD family member 6 1.40 1.05 0.0008 0.0014 0.0268 0.0221
SMAD7 SMAD family member 7 transcript variant X2 1.70 - 0.0030 - 0.0424 -
PPP2R1B protein phosphatase 2 regulatory subunit A beta 2.64 2.24 0.0020 0.0032 0.0373 0.0319
BMP2 bone morphogenetic protein 2 2.87 3.53 0.0016 0.0034 0.0335 0.0329
ID2 inhibitor of DNA binding 2 dominant negative helix-loop-helix protein 1.57 1.28 0.0016 0.0008 0.0336 0.0175
LTBP2 latent transforming growth factor beta binding protein 2 - 1.13 - 0.0054 - 0.0409
BMP4 bone morphogenetic protein 4 transcript variant X1 2.32 1.84 0.0010 0.0004 0.0293 0.0126
CDKN2B cyclin-dependent kinase inhibitor 2B 3.83 3.49 0.0022 0.0002 0.0383 0.0112
LOC102187369 bone morphogenetic protein 8A-like 5.16 4.98 0.0035 0.0032 0.0442 0.0320
INHBB inhibin beta B - 1.73 - 0.0066 - 0.0454
Notch related
DTX2 deltex homolog 2 1.29 1.50 0.0027 0.0012 0.0409 0.0205
JAG2 jagged 2 1.19 1.00 0.0023 0.0065 0.0391 0.0450
JAG1 jagged-1 1.53 1.21 0.0024 0.0024 0.0397 0.0277