TABLE 6.
Genes upregulated in the benomyl and MDR experiments
| Function group and name | Functiona | Cap1p binding site position(s)b | Fold increase (−) in expt
|
|
|---|---|---|---|---|
| MDR | Benomyl | |||
| Other | ||||
| IPF3080 | Unknown | −213, −708 | 4.1 | 1.6 |
| IPF1617 | Unknown | −207 | 7.3 | 3.2 |
| IPF11023 | Unknown | 4.3 | 2.6 | |
| Transport (CaMDR1) | Multidrug transporter activity; similar to S. cerevisiae FLR1 | −532 | 44.0 | 12.6 |
| Response to stress | ||||
| IPF18418 | Unknown; similar to S. cerevisiae YHR029c (induced by cell-damaging conditions) | 5.4 | 1.6 | |
| IPF13316 | Unknown; similar to S. cerevisiae YNL010w (induced by cell-damaging conditions) | 4.1 | 1.7 | |
| IPF5987 | Unknown; similar to S. cerevisiae YPR127w (protein with similarity to S. pombe pyridoxal reductase, aldo-keto reductase family) | 70.2 | 7.9 | |
| IPF17186 | Unknown; similar to S. cerevisiae YDR533c (induced by cell-damaging conditions) | −720 | 102.5 | 56.8 |
| PYC2 | Pyruvate carboxylase 2; similar to S. cerevisiae YBR218c | 5.1 | 1.9 | |
| GPX1 | Glutathione peroxidase; similar to S. cerevisiae HYR1 | 9.4 | 3.6 | |
| GRP2 | Reductase; similar to S. cerevisiae YOL151w (induced by osmotic stress) | −444 | 52.5 | 35.1 |
| IPF7817 | Putative NADH-dependent flavin oxidoreductase by homology; similar to S. cerevisiae OYE3 | −743 | 14.7 | 37.0 |
| DDR48 | Stress protein; similar to S. cerevisiae YMR173w (involved in the production of or recovery from mutation) | 5.6 | 1.7 | |
| IFD1 | Benzyl alcohol dehydrogenase activity (by homology); similar to S. cerevisiae YPL088w (aldo-keto reductase family) | 748.3 | 32.6 | |
| IFD4 | Benzyl alcohol dehydrogenase activity (by homology); similar to S. cerevisiae YPL088w (aldo-keto reductase family) | 129.6 | 6.7 | |
| IFD5 | Benzyl alcohol dehydrogenase activity (by homology); similar to S. cerevisiae YPL088w (aldo-keto reductase family) | 511.2 | 16.1 | |
| IFD7 | Benzyl alcohol dehydrogenase activity (by homology); similar to S. cerevisiae YPL088w (aldo-keto reductase family) | 158.9 | 5.4 | |
a
Gene functions were obtained using the CandidaDB and MycoPathPD databases available from the Pasteur Institute and from Incyte.
b
The sequence of the Cap1p-binding site considered is TTA(C/G)TAA (15).