Table 2. Algorithm validation results of full RSV-positive cohort and specific disease pathophysiology against the Canadian Institute of Health Information—Discharge Abstract Database.
| N = 2287 | Hospitalized RSV* | Bronchiolitis | Apnea | Pneumonia | URTI |
|---|---|---|---|---|---|
| Sensitivity (95% CI) | 97.9 (95.5, 99.2) | 94.6 (91.3, 97.0) | 44.4 (13.7, 78.8) | 34.0 (21.2, 48.8) | 14.3 (1.8, 42.8) |
| Specificity (95% CI) | 99.6 (98.2, 99.8) | 99.3 (98.8, 99.6) | 100 (99.8, 100) | 99.6 (99.2, 99.8) | 100 (99.8, 100) |
| Positive predictive value (95% CI) | 96.9 (94.2, 98.6) | 94.6 (91.3, 97.0) | 80.0 (28.4, 99.5) | 63.0 (42.4, 80.6) | 100 (15.8, 100) |
| Negative predictive value (95% CI) | 99.4 (99.4, 99.9) | 99.3 (98.8, 99.6) | 99.8 (99.5, 99.9) | 98.5 (98.0, 99.0) | 99.5 (99.1, 99.7) |
Abbreviations: CI = Confidence Interval; RSV = Respiratory Syncytial Virus; URTI = Upper Respiratory Tract Infection.
*Full algorithm used for “Hospitalized RSV” was any of the following: J12.1, J20.5, J21.0, and B97.4.
**Exact 95% CIs were calculated using the binomial distribution.