Fig 1. The continuum model of MscL [5] which is embedded in a continuum implicit model bilayer.

(A) Lipid with three different acyl chain length (i.e. di-10:0, di-16:0 and of di-24:1) have been simulated using finite element (FE) method for positive, zero and negative mismatches between the protein and the lipid bilayer respectively. (B) The influence of inward (negative) and outward (positive) local membrane bending on the channel deformation. Depending on the direction of curvature, different parts of the channel experience tension or compression.