Fig 5. Expression of h-proIAPP in C. elegans correlates with growth retardation phenotype.

Developmental phenotype was studied in transgenic h-proIAPP C. elegans model, transgenic m-proIAPP C. elegans model and pBX1 control animals by quantifying the number of animals in the larvae 1 (L1) to larvae 3 (L3) stages (open bars) versus larvae 4 (L4) and adult stages (filled bars) seventy-two hours after ten to fifteen gravid hermaphrodites were treated with bleach to release eggs. Data represent the percentage of animals found at larvae 1 to larvae 3 stages and the percentage of animals found at larvae 4 and adult stages ± S.D. p<0.05 versus respective control, n = 3.