TABLE 1.

Structures and activities of compounds tested against L. donovani-infected macrophagesa^a

^aT/+, toxic to macrophages but parasites still present; (T), toxic to macrophages at 10 μM and at 3 μM; (t), some toxicity towards macrophages observed at >10 μM; *, the ED₅₀ of 98N217 against L. mexicana-infected macrophages was 5.77 μM, although toxicity was observed at 10 μM. Compounds with an ED₅₀ of >10 μM were 97/657, NG60, NG78, NG73, NG 71, 97N608, NG35, NG112, 98/130, and 96/422.