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. Author manuscript; available in PMC: 2016 Mar 9.
Published in final edited form as: Bioconjug Chem. 2015 Nov 5;26(12):2315–2323. doi: 10.1021/acs.bioconjchem.5b00568

Figure 1.

Figure 1

Top panel: Structural illustration of dendrimeric molecules for BIRDS. Paramagnetic bifunctional chelates (isothiocyanate linked TmDOTA) were conjugated onto the primary amines of PAMAM dendrimers (up to 4th generation). Bottom panel: NMR spectra of (M) Monomer (i.e. TmDOTA), (G1) G1-PAMAM-(TmDOTA)6, (G2) G2-PAMAM-(TmDOTA)12, (Rhodamine-G2) Rhodamine-G2-PAMAM-(TmDOTA)12, (G3) G3-PAMAM-(TmDOTA)25, (G4) G4-PAMAM-(TmDOTA)39 at 35 °C and pH 7.4.