Table 2.

Efficacy of time-driven and event-driven PrEP in macaques

Regimen (number of FTC/TDF pills)*	Macaque species	Route of virus exposure	No. animals infected/total	Reduction in risk of SHIV infection¥
Time-driven
3d before/2h after (1:1)	Rhesus	Rectal	1/6	15.4; p=0.008
7d before/2h after (1:1)	Rhesus	Rectal	2/6	9.3; p=0.003
Event-driven
24h before/2h after (1:1)	Rhesus	Rectal	1/6	16.7; p=0.006
2h before/24h after (1:1)	Rhesus	Rectal	3/6	4.1; p=0.02
2h before/2h after (2:2)	Rhesus	Rectal	1/6	15.4; p=0.008

^*relative to the time of SHIV exposure;

^¥compared to the untreated control group