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. Author manuscript; available in PMC: 2016 Mar 9.
Published in final edited form as: Hippocampus. 2012 Mar 19;22(9):1795–1808. doi: 10.1002/hipo.22013

FIGURE 7.

FIGURE 7

Irradiation impaired cognitive flexibility required with the addition of a shock zone. (A) Schematic of behavioral procedures. (B) Initial training: X- (N = 8) and sham-irradiated (N = 7) mice did not differ in the average number of times they entered the stationary shock zone during six initial training trials (F1,13 = 0.67, P = 0.43). (C, D). After the conditions of the task were changed, there was a significant effect of treatment (sham vs. irradiation) (F1,312 = 5.88, P < 0.05) and a significant treatment ×shock zone (initial vs. new) interaction (F1,312 = 4.70, P < 0.05). Post-hoc tests: Average entrances of irradiated mice into initial stationary shock zone = average entrances of sham mice into initial stationary shock zone. Average entrances of irradiated mice into new rotating shock zone > average entrances of sham mice into new rotating shock zone. Error bars represent S.E.M. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]