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(A) Course of infection in human whole blood following exposure to increasing concentrations of isoniazid. Drug was added at 1 day postinfection. (B) Effects of increasing C/MIC ratios on the intracellular bactericidal activity of isoniazid against M. tuberculosis in whole blood 2 days after drug addition. Each point represents the mean ± standard deviation of triplicate values. The bactericidal effect is calculated on the basis of the initial inoculum prior to addition of isoniazid.
