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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Nat Med. 2015 Aug;21(8):846–853. doi: 10.1038/nm.3915

Figure 3.

Figure 3

Influences on cancer cell state. The cancer cell state is representative of the genetic and epigenetic components as well as the signaling environment, which collectively determine which genes are expressed by the cell. These properties may be altered by subclonal evolution and can influence the initiation, progression and drug response of the tumor, affecting both the bulk tumor and the single-cell state. The gray arrows show the timescales of these processes and the factors that might influence cell state on each timescale are indicated.