TABLE 1.
MICs of agents
| Organism (no. of β-lactamase-positive strains/no. tested) and drug | MIC (μg/ml)a
|
||
|---|---|---|---|
| MIC | 50% | 90% | |
| Bacteroides fragilis (11/11) | |||
| WCK 771 | 1->32 | 1 | 16 |
| Ciprofloxacin | 2->32 | 4 | >32 |
| Levofloxacin | 1->32 | 2 | 32 |
| Gatifloxacin | 0.5->32 | 0.5 | 16 |
| Moxifloxacin | 0.5->32 | 0.5 | 8 |
| Piperacillin | 2->128 | 16 | >128 |
| Piperacillin-tazobactam | 0.5-4 | 2 | 2 |
| Imipenem | 0.06-2 | 0.25 | 2 |
| Metronidazole | 0.25-1 | 1 | 1 |
| Clindamycin | 0.125-2 | 2 | 2 |
| Bacteroides thetaiotaomicron (11/11) | |||
| WCK 771 | 1-8 | 1 | 2 |
| Ciprofloxacin | 16->32 | 16 | >32 |
| Levofloxacin | 4->32 | 4 | 8 |
| Gatifloxacin | 1-32 | 2 | 4 |
| Moxifloxacin | 1-16 | 2 | 2 |
| Piperacillin | 16-64 | 64 | 64 |
| Piperacillin-tazobactam | 4-16 | 16 | 16 |
| Imipenem | 0.125-0.5 | 0.5 | 0.5 |
| Metronidazole | 0.5-1 | 1 | 1 |
| Clindamycin | 0.125->32 | 4 | >32 |
| Bacteroides distasonis (6/11) | |||
| WCK 771 | 1-2 | 2 | 2 |
| Ciprofloxacin | 4-16 | 4 | 8 |
| Levofloxacin | 1-4 | 2 | 2 |
| Gatifloxacin | 0.5-2 | 1 | 2 |
| Moxifloxacin | 0.25-1 | 0.5 | 1 |
| Piperacillin | 4->128 | 64 | >128 |
| Piperacillin-tazobactam | 4-16 | 4 | 4 |
| Imipenem | 0.5-1 | 1 | 1 |
| Metronidazole | 0.5-1 | 1 | 1 |
| Clindamycin | 0.03->32 | 8 | 16 |
| Bacteroides vulgatus (10/10) | |||
| WCK 771 | 0.25-16 | 0.5 | 16 |
| Ciprofloxacin | 16->32 | 16 | 32 |
| Levofloxacin | 1->32 | 2 | >32 |
| Gatifloxacin | 0.5-16 | 0.5 | 16 |
| Moxifloxacin | 0.25-16 | 0.5 | 16 |
| Piperacillin | 8->128 | 16 | >128 |
| Piperacillin-tazobactam | 0.25->32 | 4 | 8 |
| Imipenem | 0.25-2 | 1 | 1 |
| Metronidazole | 0.25-2 | 1 | 2 |
| Clindamycin | ≤0.016->32 | 0.03 | 0.5 |
| Miscellaneous Bacteroides (11/11)b | |||
| WCK 771 | 1-8 | 2 | 4 |
| Ciprofloxacin | 8->32 | 8 | >32 |
| Levofloxacin | 4->32 | 4 | >32 |
| Gatifloxacin | 1-16 | 2 | 16 |
| Moxifloxacin | 1-16 | 1 | 8 |
| Piperacillin | 16->128 | 128 | >128 |
| Piperacillin-tazobactam | 1-8 | 2 | 8 |
| Imipenem | 0.125-1 | 0.5 | 0.5 |
| Metronidazole | 0.25-2 | 1 | 2 |
| Clindamycin | 0.5->32 | 4 | >32 |
| Bacteroides fragilis group (49/54) | |||
| WCK 771 | 0.25->32 | 1 | 8 |
| Ciprofloxacin | 2->32 | 16 | >32 |
| Levofloxacin | 1->32 | 4 | 32 |
| Gatifloxacin | 0.5->32 | 1 | 16 |
| Moxifloxacin | 0.25->32 | 1 | 8 |
| Piperacillin | 2->128 | 32 | >128 |
| Piperacillin-tazobactam | 0.25->32 | 4 | 16 |
| Imipenem | 0.06-2 | 0.5 | 1 |
| Metronidazole | 0.25-2 | 1 | 1 |
| Clindamycin | ≤0.016->32 | 2 | >32 |
| Prevotella bivia (26/42) | |||
| WCK 771 | 0.25->32 | 1 | 1 |
| Ciprofloxacin | 8->32 | 16 | 8 |
| Levofloxacin | 2->32 | 4 | 8 |
| Gatifloxacin | 1->32 | 4 | 4 |
| Moxifloxacin | 2->32 | 4 | 4 |
| Piperacillin | 1-128 | 4 | 32 |
| Piperacillin-tazobactam | ≤0.125 | ≤0.125 | ≤0.125 |
| Imipenem | 0.03-0.25 | 0.03 | 0.06 |
| Metronidazole | 0.5-8 | 2 | 4 |
| Clindamycin | ≤0.016->32 | 0.03 | 0.06 |
| Prevotella corporis (4/12) | |||
| WCK 771 | 0.06-1 | 0.125 | 0.25 |
| Ciprofloxacin | 0.5-2 | 1 | 1 |
| Levofloxacin | 0.5-1 | 1 | 1 |
| Gatifloxacin | 0.25-0.5 | 0.25 | 0.5 |
| Moxifloxacin | 0.5-1 | 0.5 | 1 |
| Piperacillin | ≤0.125-32 | 1 | 16 |
| Piperacillin-tazobactam | ≤0.125 | ≤0.125 | ≤0.125 |
| Imipenem | 0.016-0.06 | 0.03 | 0.06 |
| Metronidazole | ≤0.125-1 | 0.25 | 0.5 |
| Clindamycin | ≤0.016-32 | ≤0.016 | ≤0.016 |
| Prevotella intermedia (6/10) | |||
| WCK 771 | 0.06-1 | 0.125 | 0.125 |
| Ciprofloxacin | 0.5-8 | 1 | 1 |
| Levofloxacin | 0.5-8 | 0.5 | 1 |
| Gatifloxacin | 0.25-2 | 0.25 | 0.5 |
| Moxifloxacin | 0.25-8 | 0.5 | 0.5 |
| Piperacillin | ≤0.125-16 | 2 | 8 |
| Piperacillin-tazobactam | ≤0.125 | ≤0.125 | ≤0.125 |
| Imipenem | ≤0.008-0.125 | 0.03 | 0.03 |
| Metronidazole | 0.25-0.5 | 0.25 | 0.5 |
| Clindamycin | ≤0.016->32 | ≤0.016 | ≤0.016 |
| Prevotella melaninogenica (9/10) | |||
| WCK 771 | 0.125-8 | 0.125 | 8 |
| Ciprofloxacin | 1-16 | 2 | 8 |
| Levofloxacin | 1-32 | 1 | 16 |
| Gatifloxacin | 0.25-16 | 1 | 16 |
| Moxifloxacin | 0.5-16 | 1 | 16 |
| Piperacillin | 0.5-64 | 4 | 64 |
| Piperacillin-tazobactam | ≤0.125 | ≤0.125 | ≤0.125 |
| Imipenem | ≤0.008-0.125 | 0.016 | 0.125 |
| Metronidazole | 0.25-0.5 | 0.25 | 0.5 |
| Clindamycin | ≤0.016-0.03 | ≤0.016 | ≤0.016 |
| Prevotella buccae (2/11) | |||
| WCK 771 | 0.125-0.5 | 0.25 | 0.5 |
| Ciprofloxacin | 1-4 | 2 | 4 |
| Levofloxacin | 0.5-1 | 1 | 1 |
| Gatifloxacin | 0.25-0.5 | 0.25 | 0.5 |
| Moxifloxacin | 0.25-0.5 | 0.5 | 0.5 |
| Piperacillin | 1-8 | 2 | 4 |
| Piperacillin-tazobactam | ≤0.016 | ≤0.125 | ≤0.125 |
| Imipenem | 0.03-0.06 | 0.06 | 0.06 |
| Metronidazole | 0.5-2 | 1 | 2 |
| Clindamycin | ≤0.016-0.03 | ≤0.016 | ≤0.016 |
| Miscellaneous Prevotella and Porphyromonas (9/19)c | |||
| WCK 771 | 0.03-1 | 0.125 | 0.5 |
| Ciprofloxacin | 0.5-4 | 1 | 2 |
| Levofloxacin | 0.125-8 | 1 | 1 |
| Gatifloxacin | 0.06-2 | 0.25 | 0.5 |
| Moxifloxacin | 0.125-1 | 0.5 | 1 |
| Piperacillin | ≤0.125-128 | 8 | 128 |
| Piperacillin-tazobactam | ≤0.125-8 | ≤0.125 | ≤0.125 |
| Imipenem | ≤0.008-0.25 | 0.03 | 0.125 |
| Metronidazole | ≤0.125-4 | 0.5 | 4 |
| Clindamycin | ≤0.016->32 | ≤0.016 | 0.06 |
| Prevotella and Porphyromonas (56/104) | |||
| WCK 771 | 0.03->32 | 0.25 | 1 |
| Ciprofloxacin | 0.5->32 | 2 | 32 |
| Levofloxacin | 0.125->32 | 1 | 8 |
| Gatifloxacin | 0.06->32 | 0.5 | 4 |
| Moxifloxacin | 0.125->32 | 1 | 4 |
| Piperacillin | ≤0.125-128 | 4 | 64 |
| Piperacillin-tazobactam | ≤0.125-8 | ≤0.125 | ≤0.125 |
| Imipenem | ≤0.008-0.25 | 0.03 | 0.125 |
| Metronidazole | ≤0.125-8 | 1 | 4 |
| Clindamycin | ≤0.016->32 | ≤0.016 | 0.06 |
| Fusobacterium nucleatum (0/12) | |||
| WCK 771 | 0.125-0.5 | 0.25 | 0.25 |
| Ciprofloxacin | 2-4 | 2 | 4 |
| Levofloxacin | 0.5-2 | 1 | 2 |
| Gatifloxacin | 0.25-0.5 | 0.25 | 0.5 |
| Moxifloxacin | 0.125-0.25 | 0.25 | 0.25 |
| Piperacillin | ≤0.125 | ≤0.125 | ≤0.125 |
| Piperacillin-tazobactam | ≤0.125 | ≤0.125 | ≤0.125 |
| Imipenem | ≤0.008-0.06 | 0.03 | 0.06 |
| Metronidazole | ≤0.125-0.5 | ≤0.125 | 0.25 |
| Clindamycin | ≤0.016-0.06 | 0.06 | 0.06 |
| Fusobacterium necrophorum (0/12) | |||
| WCK 771 | 0.25-1 | 1 | 1 |
| Ciprofloxacin | 1-4 | 2 | 2 |
| Levofloxacin | 1-4 | 2 | 2 |
| Gatifloxacin | 0.25-1 | 0.5 | 1 |
| Moxifloxacin | 0.25-2 | 1 | 2 |
| Piperacillin | ≤0.125-2 | ≤0.125 | ≤0.125 |
| Piperacillin-tazobactam | ≤0.125-1 | ≤0.125 | ≤0.125 |
| Imipenem | ≤0.008-1 | 0.016 | 0.06 |
| Metronidazole | ≤0.125-0.25 | ≤0.125 | 0.25 |
| Clindamycin | ≤0.016-0.125 | 0.06 | 0.06 |
| Fusobacterium mortiferum (2/11) | |||
| WCK 771 | 0.125-0.5 | 0.125 | 0.25 |
| Ciprofloxacin | 0.5-4 | 2 | 2 |
| Levofloxacin | 1-2 | 1 | 2 |
| Gatifloxacin | 0.25-1 | 0.5 | 0.5 |
| Moxifloxacin | 0.5-1 | 0.5 | 1 |
| Piperacillin | 0.25->128 | 0.5 | >128 |
| Piperacillin-tazobactam | ≤0.125-1 | 0.25 | 1 |
| Imipenem | 0.25-1 | 0.25 | 1 |
| Metronidazole | 0.25-0.5 | 0.25 | 0.5 |
| Clindamycin | 0.06-0.5 | 0.125 | 0.125 |
| Fusobacterium varium (0/12) | |||
| WCK 771 | 4->32 | 8 | 16 |
| Ciprofloxacin | 4->32 | 8 | 16 |
| Levofloxacin | 4->32 | 4 | 8 |
| Gatifloxacin | 2->32 | 4 | 4 |
| Moxifloxacin | 2->32 | 4 | 8 |
| Piperacillin | 4-32 | 8 | 32 |
| Piperacillin-tazobactam | 2-16 | 8 | 8 |
| Imipenem | 0.5-2 | 1 | 2 |
| Metronidazole | ≤0.125-1 | ≤0.125 | 0.5 |
| Clindamycin | 2->32 | 32 | >32 |
| Fusobacteria (2/47) | |||
| WCK 771 | 0.125->32 | 0.5 | 8 |
| Ciprofloxacin | 0.5->32 | 2 | 8 |
| Levofloxacin | 0.5->32 | 2 | 4 |
| Gatifloxacin | 0.25->32 | 0.5 | 4 |
| Moxifloxacin | 0.125->32 | 1 | 4 |
| Piperacillin | ≤0.125->128 | 0.25 | 16 |
| Piperacillin-tazobactam | ≤0.125-16 | ≤0.125 | 8 |
| Imipenem | ≤0.008-2 | 0.25 | 1 |
| Metronidazole | ≤0.125-1 | ≤0.125 | 0.25 |
| Clindamycin | ≤0.016->32 | 0.06 | 32 |
| Peptostreptococci (0/27)d | |||
| WCK 771 | 0.03-4 | 0.5 | 1 |
| Ciprofloxacin | 0.25-16 | 1 | 4 |
| Levofloxacin | 0.25-16 | 2 | 4 |
| Gatifloxacin | 0.125-8 | 0.5 | 1 |
| Moxifloxacin | 0.125-4 | 0.25 | 0.5 |
| Piperacillin | ≤0.125-2 | ≤0.125 | 0.25 |
| Piperacillin-tazobactam | ≤0.125-2 | ≤0.125 | 0.25 |
| Imipenem | 0.016-0.5 | 0.06 | 0.125 |
| Metronidazole | ≤0.125-4 | 0.5 | 2 |
| Clindamycin | ≤0.016-8 | 0.125 | 1 |
| Propionibacteria (0/20) | |||
| WCK 771 | 0.125-1 | 0.125 | 0.125 |
| Ciprofloxacin | 0.5-1 | 1 | 1 |
| Levofloxacin | 0.25-0.5 | 0.5 | 0.5 |
| Gatifloxacin | 0.25 | 0.25 | 0.25 |
| Moxifloxacin | 0.25-0.5 | 0.25 | 0.25 |
| Piperacillin | 0.5-2 | 1 | 2 |
| Piperacillin-tazobactam | ≤0.125-2 | 0.25 | 1 |
| Imipenem | 0.016-0.06 | 0.03 | 0.06 |
| Metronidazole | >16 | >16 | >16 |
| Clindamycin | 0.03-0.25 | 0.06 | 0.125 |
| Lactobacillus (0/12) | |||
| WCK 771 | 1-32 | 2 | 16 |
| Ciprofloxacin | 1->32 | 2 | >32 |
| Levofloxacin | 1->32 | 2 | >32 |
| Gatifloxacin | 0.25-16 | 0.5 | 8 |
| Moxifloxacin | 0.25-8 | 0.5 | 8 |
| Piperacillin | 1-2 | 2 | 2 |
| Piperacillin-tazobactam | 1-2 | 2 | 2 |
| Imipenem | 0.25-4 | 1 | 2 |
| Metronidazole | 16->16 | >16 | >16 |
| Clindamycin | 0.125-4 | 0.5 | 4 |
| Eubacterium lentum (0/11) | |||
| WCK 771 | 0.25-0.5 | 0.5 | 0.5 |
| Ciprofloxacin | 0.5-1 | 0.5 | 1 |
| Levofloxacin | 0.5 | 0.5 | 0.5 |
| Gatifloxacin | 0.25 | 0.25 | 0.25 |
| Moxifloxacin | 0.125-0.25 | 0.25 | 0.25 |
| Piperacillin | 16-32 | 16 | 16 |
| Piperacillin-tazobactam | 16 | 16 | 16 |
| Imipenem | 0.5 | 0.5 | 0.5 |
| Metronidazole | 0.25-1 | 0.5 | 1 |
| Clindamycin | 0.125->32 | 0.125 | 0.25 |
| Other gram-positive non-spore- forming bacilli (0/15)e | |||
| WCK 771 | 0.25-2 | 1 | 2 |
| Ciprofloxacin | 0.5-32 | 4 | 16 |
| Levofloxacin | 1-8 | 4 | 4 |
| Gatifloxacin | 0.25-2 | 1 | 2 |
| Moxifloxacin | 0.25-2 | 2 | 2 |
| Piperacillin | ≤0.125-4 | 0.5 | 2 |
| Piperacillin-tazobactam | ≤0.125-2 | 0.5 | 2 |
| Imipenem | 0.016-0.5 | 0.125 | 0.25 |
| Metronidazole | 0.5->16 | >16 | >16 |
| Clindamycin | ≤0.016->32 | 0.03 | >32 |
| Clostridium perfringens (0/25) | |||
| WCK 771 | 0.03-0.25 | 0.06 | 0.25 |
| Ciprofloxacin | 0.25-1 | 0.5 | 1 |
| Levofloxacin | 0.25-2 | 0.5 | 1 |
| Gatifloxacin | 0.25-1 | 0.5 | 0.5 |
| Moxifloxacin | 0.25-1 | 0.5 | 0.5 |
| Piperacillin | ≤0.125-1 | 0.5 | 1 |
| Piperacillin-tazobactam | ≤0.125-1 | 0.25 | 0.5 |
| Imipenem | 0.06-0.5 | 0.125 | 0.25 |
| Metronidazole | 0.5-2 | 1 | 1 |
| Clindamycin | 0.03-2 | 0.5 | 2 |
| Clostridium difficile (0/12) | |||
| WCK 771 | 0.5-4 | 0.5 | 1 |
| Ciprofloxacin | 8->32 | 16 | 16 |
| Levofloxacin | 4->32 | 4 | 8 |
| Gatifloxacin | 1-16 | 2 | 2 |
| Moxifloxacin | 1-8 | 1 | 2 |
| Piperacillin | 8-16 | 8 | 16 |
| Piperacillin-tazobactam | 8-32 | 8 | 16 |
| Imipenem | 4-8 | 8 | 8 |
| Metronidazole | ≤0.125-0.5 | 0.25 | 0.25 |
| Clindamycin | 4->32 | 8 | >32 |
| Miscellaneous clostridia (0/23)f | |||
| WCK 771 | 0.03-1 | 0.125 | 1 |
| Ciprofloxacin | 0.25-8 | 2 | 8 |
| Levofloxacin | 0.25-8 | 1 | 8 |
| Gatifloxacin | 0.25-4 | 0.5 | 4 |
| Moxifloxacin | 0.25-4 | 0.5 | 2 |
| Piperacillin | ≤0.125-64 | 1 | 16 |
| Piperacillin-tazobactam | ≤0.125-32 | 0.25 | 8 |
| Imipenem | 0.03-1 | 0.25 | 0.5 |
| Metronidazole | ≤0.125-4 | 1 | 4 |
| Clindamycin | 0.03->32 | 2 | 16 |
| All strains (107/350) | |||
| WCK 771 | 0.03->32 | 0.5 | 2 |
| Ciprofloxacin | 0.25->32 | 2 | 32 |
| Levofloxacin | 0.125->32 | 1 | 8 |
| Gatifloxacin | 0.06->32 | 0.5 | 4 |
| Moxifloxacin | 0.125->32 | 0.5 | 4 |
| Piperacillin | ≤0.125->128 | 2 | 64 |
| Piperacillin-tazobactam | ≤0.125->32 | ≤0.125 | 8 |
| Imipenem | ≤0.008-8 | 0.125 | 1 |
| Metronidazole | ≤0.125->16 | 1 | >16 |
| Clindamycin | ≤0.016->32 | 0.125 | 16 |
a
50% and 90%, MICs at which 50 and 90% of isolates are inhibited, respectively.
b
Bacteroides ovatus, 7; Bacteroides uniformis, 4.
c
Prevotella disiens, 9; Prevotella oris, 3; Prevotella loeschii, 2; Prevotella oralis group, 1; Prevotella denticola, 1; Porphyromonas asaccharolytica, 2; Porphyromonas gingivalis, 1.
d
Peptostreptococcus asaccharolyticus, 2; Peptostreptococcus magnus, 6; Peptostreptococcus micros, 6; Peptostreptococcus anaerobius, 5; Peptostreptococcus tetradius, 6; Peptostreptococcus prevotii, 2.
e
Actinomyces sp., 6; Bifidobacterium sp., 9.
f
Clostridium tertium, 6; Clostridium bifermentans, 3; Clostridium cadaveris, 3; Clostridium sordellii, 4; Clostridium ramosum, 3; Clostridium paraputrificum, 1; Clostridium hystoliticum, 1; Clostridium sp., 2.