Table 1.
European Studies of HNF4A-, GCK-, and HNF1A-MODY by Nation
| Nation | Latitude | Study Participants | Undiag. MODY | Genetic MODY | HNF4A-MODY | GCK-MODY | HNF1A-MODY | Ratio of GCK/HNF1A MODY | Source |
|---|---|---|---|---|---|---|---|---|---|
| Norway | 57°57′–80°49′ | >1500† | >69% (>1,042) | <31% (458) | <3% (40) | <9% (139) | <14% (208) | 0.67 | (27) |
| Denmark | 54°34′–57°45′ | 78 | 51% (40) | 49% (38) | 3% (2) | 10% (8) | 36% (28) | 0.29 | (34) |
| Netherlands | 50°45′–53°32′ | 1,319 | 65% (817) | 39% (502) | 6% (76) | 15% (204) | 17% (222) | 0.92 | (26) |
| UK | 49°51′–60°51′ | 2,072 | 73% (1,508) | 27% (564) | 3% (56) | 9% (180) | 14% (293) | 0.61 | (24) |
| Poland | 49°00′–54°50′ | 1351 | 93% (1251) | 7% (100) | <0.3% (4*) | 6.2% (84) | <0.3% (4*) | 21* | (31) |
| Germany/Austria | 47°17′–55°03′, 46°23′–49°01′ | 272 | 3% (9) | 97% (263) | 4% (10) | 62% (169) | 31% (84) | 2.0 | (29) |
| Czech Rep. | 48°33′–51°02′ | 61 | 52% (32) | 48% (29) | 5% (3) | 31% (19) | 11.5% (7) | 2.7 | (39) |
| Italy | 35°30′–47°05′ | 172, 58 | 30% (51), 22% (13) | 70% (121), 78% (45) | N/A, 5% (3) | 63% (109), 53% (31) | 7% (12), 16% (9) | 9.1, 3.4 | (35, 36) |
| Greece | 34°49′–41°43′ | 134 | 34% (46) | 66% (88) | N/A | 54% (72) | 12% (16) | 4.5 | (41) |
| Spain | 28°38′–43°47′ | 95 | 11% (10) | 89% (85) | 0% (0) | 80% (76) | 8% (8) | 9.5 | (40) |
†
Study did not provide precise number of registry participants
*
Study did not differentiate between HNF1A and HNF4A mutations