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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Neurobiol Dis. 2016 Feb 11;89:202–212. doi: 10.1016/j.nbd.2016.02.011

Figure 6. Intranasal administration of miR-210-LNA produced a neuroprotective effect.

Figure 6

Rat pups received via intranasal administration of the negative control (Neg. Ctrl) or miR-210-LNA (LNA) 4 hours after the HI treatment. Ctrl, sham control without HI. (A) MiR-210 levels in the ipsilateral hemisphere 24 hours after HI. n=5. (B) Brain infarct size 48 hours after HI. n=7-8. For panels C to F, neurological function recovery determined six weeks after the HI. (C-E) Water maze tests of cued training (C), spatial leaning (D) and spatial memory (E). (F) Rotarod tests. n=9-10. * P<0.05, LNA vs. Neg. Ctrl.