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Cumulative concentration of Cu ions released from Ti6Al4V5Cu alloys and the average release rates. The data indicated that the release of Cu ions was continuous from Ti6Al4V5Cu alloy in saline and the accumulated concentration was increased with time in 24 h, but not in a linear trend. At the beginning, Cu ions kept a high releasing rate, however, the rate slowed down with time. It was these Cu ions released in the early stage that played the antibacterial role.
