TABLE 1.
Comparison of physicochemical parameters of the peptides used in this study with their effects on L. donovani promastigotesa
| Peptide | H (kcal/mol)b | μb | tr (min)b | ED50 (μM) for hemolysisb | MICbc (μM) |
L. donovani promastigotes
|
|||
|---|---|---|---|---|---|---|---|---|---|
| Inhibition of proliferation
|
Inhibition of MTT reduction
|
||||||||
| LD50 (μM) | LD90 (μM) | ED50 (μM) | ED90 (μM) | ||||||
| MG-H1 | −17.7 | 0.596 | 31.5 | 2.9 | 16 | 2.4 | 4.3 | 5.0 | 20.0 |
| MG-H2 | −17.7 | 0.607 | 21.7 | 16 | 2 | 0.9 | 1.0 | 1.8 | 4.6 |
| F5W-magainin 2 | −12.6 | 0.488 | 17.6 | >1,000 | 8 | 6.1 | 9.2 | 8.3 | 24.0 |
a
Abbreviations: H, Hydrophobicity of the nonpolar face; μ, hydrophobic moment tr, reverse-phase high-performance liquid chromatography retention time.
b
Data are taken from Tachi et al. (29).
c
MICs are those for E. coli.