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Effects of ellipticine, ET-1, and ET-2 on DNA cleavage mediated by human topoisomerase IIα. Results for ellipticine (ET; black), ET-1 (ET-1; red), and ET-2 (ET-2; blue) on the generation of enzyme-mediated double-stranded DNA breaks are shown. DNA cleavage levels were calculated relative to control reactions that contained no drug and were set to 100%. Error bars represent standard deviations for at least three independent experiments.
