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Effects of ET-1 and ET-2 on the binding of negatively supercoiled plasmid by human topoisomerase IIα. Results of an electrophoretic mobility shift assay are shown for an enzyme titration carried out in the presence of no compound, 25 μM ET-1, or 25 μM ET-2. Enzyme-DNA binding is indicated by the shift of the DNA from the position of negatively supercoiled [(−)SC] plasmid to the origin. Gels are representative of three independent experiments.
