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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Mucosal Immunol. 2015 Sep 9;9(3):718–729. doi: 10.1038/mi.2015.95

Figure 4. Administration of recombinant IL-17A and IL-17A/F, but not IL-17F, rescues bacterial clearance, neutrophil recruitment and cytokine production in the lungs of Il-17a−/− mice following L. pneumophila infection.

Figure 4

Intratracheal administration of BSA (as control; 1 μg/mouse) or 1 μg/50μl/mouse of rm-IL-17A, rmIL-17A/F, or rm-IL-17F to L. pneumophila infected IL-17A−/− mice 1 h postinfection. BALF and lung tissues were harvested at 72 h after L. pneumophila infection. CFU in the lung (A) and liver (B), total leukocytes (WBC) and neutrophils (PMN) in BALF (C-D), cytokine/chemokine levels in BALF and lung homogenates (E-F) were quantified at 72 h postinfection. *Indicates difference between control (BSA) and cytokine administered mice. n = 6-10 mice in each group at each time-point. *p < 0.05, **p < 0.01,*** p < 0.001.