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. 2015 Oct 26;78(2):203–211. doi: 10.1292/jvms.15-0346

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©2016 The Japanese Society of Veterinary Science

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.

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Fig. 3. — Effects of SKF96365 (SKF) on carbachol (CCh)-induced mI_TRPC. Cells bathed in the Cs⁺-rich external solution were held under voltage clamp at −60 mV using patch pipettes filled with the Cs⁺-rich pipette solution to block any K⁺ currents. Aa and Ab show a typical current trace when SKF (10 and 30 µM) was extracellularly applied to the cell in the presence of CCh (100 µM), respectively. B shows the mean percentages of I_KATP and mI_TRPC suppressions. Each column indicates mean + 1 S.E.M. The numbers of cells used are presented in parenthesis. * in (B) represents significantly smaller inhibition of mI_TRPC induced by SKF (10 µM) relative to the I_KATP one (P<0.05). # in (B) represents significantly greater inhibition of mI_TRPC induced by SKF (30 µM) relative to the corresponding one induced by SKF (10 µM) (P<0.05).