TABLE 1.
Mean percentage and range of survival of mice 10 days after infection with Aspergillus and combination therapy with G-CSF and POS or POS monotherapy
| Treatmenta | Mean % of mice surviving infection withb
|
|||
|---|---|---|---|---|
| A. fumigatus ND158c | A. fumigatus ND208c | A. flavus ND83d,f | A. fumigatus ND208 INe | |
| G-CSF | ||||
| 0 | 0 (0) | 0 (0) | 0 | 0 |
| 125 | 0 (0) | 0 (0) | 0 | 0 |
| 600 | 0 (0) | 0 (0) | 0 | 0 |
| POS | ||||
| 0 | 0 (0) | 0 (0) | 0 | 0 |
| 5 | 0 (0) | 5.6 (0-16.7) | 33.3 | 0 |
| 25 | 8.3 (0-16.7) | 27.8 (8.3-41.7) | 75.0 | 20.0 |
| 100 | 27.8 (16.7-41.7) | 41.7 (16.7-66.7) | 83.3 | 30.0 |
| G-CSF/POS | ||||
| 125/0 | 0 (0) | 0 (0) | 0 | 0 |
| 125/5 | 5.6 (0-16.7) | 8.3 (0-25.0) | 8.3 | 0 |
| 125/25 | 5.6 (0-16.7) | 11.1 (0-33.3) | 58.3 | 10.0 |
| 125/100 | 19.4 (0-33.3) | 22.2 (0-66.7) | 66.7 | 0 |
| 600/0 | 0 (0) | 0 (0) | 0 | 0 |
| 600/5 | 2.8 (0-8.3) | 8.3 (0-25.0) | 33.3 | 0 |
| 600/25 | 5.6 (0-16.7) | 19.5 (0-41.7) | 66.7 | 10.0 |
| 600/100 | 19.4 (16.7-25.0) | 38.9 (25.0-66.7) | 66.7 | 30.0 |
Treatment doses are given in micrograms per kilogram per day for G-CSF and milligrams per kilogram per day for POS.
Values in parentheses are ranges of percent survival among experiments.
Data represent means of the results of three independent experiments with 36 mice.
Data represent the results of a single experiment with 12 mice.
Data represent the results of a single experiment with 10 mice. IN, intranasal infection.
POS was given at 0.2, 1, or 10 mg/kg/day. No significant difference was observed between the survival of mice in combination therapy and the survival of those in monotherapy groups (P value of >0.05 by Wilcoxon and log rank analyses).