TABLE 2.
MICs of β-lactams
| β-Lactama | MIC (μg/ml)
|
||||
|---|---|---|---|---|---|
| K. pneumoniae KG502(GES-4) | K. pneumoniae KG525(GES-3) | E. coli XL1-Blue pKGL502(GES-4) | E. coli XL1-Blue pKGB525(GES-3) | E. coli XL1-Blue pBCSK+ | |
| Ampicillin | >128 | >128 | >128 | >128 | 4 |
| Ampicillin + sulbactam | >128 | >128 | >128 | 2 | 2 |
| Amoxicillin | >128 | >128 | >128 | >128 | 4 |
| Amoxicillin + clavulanate | >128 | >128 | >128 | 32 | 4 |
| Piperacillin | 128 | 128 | 64 | 16 | 1 |
| Piperacillin + tazobactam | 64 | 128 | 16 | 0.5 | 1 |
| Cefotaxime | 16 | 64 | 1 | 2 | 0.13 |
| Cefotaxime + clavulanate | 16 | 8 | 0.25 | 0.06 | 0.06 |
| Cefotaxime + sulbactam | 16 | 32 | 1 | 0.06 | 0.06 |
| Cefotaxime + tazobactam | 16 | 64 | 1 | 0.06 | 0.06 |
| Ceftazidime | 1,024 | >1,024 | 64 | 128 | 0.13 |
| Ceftazidime + clavulanate | 512 | 256 | 8 | 4 | 0.06 |
| Ceftazidime + sulbactam | >128 | >128 | 32 | 0.25 | 0.13 |
| Ceftazidime + tazobactam | >128 | >128 | 32 | 0.5 | 0.13 |
| Cephaloridine | >128 | >128 | 64 | 16 | 2 |
| Cefminox | >128 | 8 | 16 | 1 | 0.5 |
| Cefoxitin | >128 | 128 | >128 | 8 | 4 |
| Moxalactam | 128 | 4 | 16 | 0.5 | 0.13 |
| Cefmetazole | >128 | 16 | 128 | 2 | 0.5 |
| Cefpirome | 128 | >128 | 1 | 2 | 0.06 |
| Cefepime | 8 | 16 | 0.25 | 0.25 | 0.06 |
| Aztreonam | 32 | 64 | 2 | 4 | 0.06 |
| Imipenem | 8 | 0.25 | 0.25 | 0.13 | 0.13 |
| Meropenem | 8 | 0.5 | 0.25 | 0.015 | 0.015 |
a
Clavulanate, tazobactam, and sulbactam were each used at a fixed concentration of 4 μg/ml.