Table 1.
Locations and mean signal intensity changes in muscle sympathetic nerve (MSNA) related changes in blood oxygen level dependent signal intensity in controls and subjects with obstructive sleep apnea (OSA) prior and following 6 and 12 months of continuous positive airway pressure (CPAP) treatment.
| Brainstem region | MNI co-ordinate | Cluster size | F-score | Mean (±SEM) signal intensity change | |||||
|---|---|---|---|---|---|---|---|---|---|
| x | y | z | Controls | OSA pre-CPAP | OSA 6 m CPAP | OSA 12 m CPAP | |||
| Medullary raphe | 2 | −40 | −58 | 11 | 5.90 | 0.16 ± 0.13 | −0.12 ± 0.09* | 0.22 ± 0.11† | 0.10 ± 0.10 |
| RVLM | |||||||||
| Left | −4 | −36 | −44 | 6 | 4.14 | 0.16 ± 0.07 | −0.07 ± 0.07* | 0.06 ± 0.06† | 0.05 ± 0.06 |
| Right | 10 | −44 | −48 | 6 | 7.20 | 0.12 ± 0.08 | −0.08 ± 0.06* | −0.18 ± 0.09*† | 0.08 ± 0.07‡ |
| dlPons | |||||||||
| Left | −2 | −30 | −22 | 51 | 12.31 | 0.16 ± 0.06 | −0.02 ± 0.09* | 0.34 ± 0.17† | 0.18 ± 0.11 |
| Right | 4 | −38 | −32 | 5 | 4.08 | 0.37 ± 0.15 | 0.08 ± 0.08* | 0.12 ± 0.06 | 0.53 ± 0.14†‡ |
| 8 | −34 | −24 | 7 | 2.90 | |||||
| Ventral midbrain | 0 | −22 | −14 | 16 | 2.78 | −0.01 ± 0.05 | −0.39 ± 0.14* | 0.30 ± 0.18*† | 0.19 ± 0.11*† |
Locations are given in Montreal Neurological Institute space.
*
Significantly different to controls.
†
Significantly different to OSA pre-CPAP.
‡
Significantly different to OSA 6 months CPAP (p < 0.05).
dlPons, dorsolateral pons; RVLM, rostral ventrolateral medulla.