Table 1.
Studies investigating the effect of subthalamic nucleus deep brain stimulation (STN-DBS) on Go/NoGo task performance in PD
| References | Med. status | N | Type of Go/NoGo task | Go trials probability | Commission error rate | Summary of results |
|---|---|---|---|---|---|---|
| Hershey et al. (2004) | Off | 24 STN-DBS PD | Letter/number Non-lateralized Response button press |
50 and 83 % CRT | NR | STN stimulation significantly reduced discriminability on high (83 %) CRT only |
| Kühn et al. (2004) | Off | 8 STN-DBS PD | Letter/number Lateralized Response button press |
80 % CRT | NR | No effect of stimulation on either error rates (commission, omission and laterality error rates) or RT |
| van den Wildenberg et al. (2006) | On | 17 STN-DBS PD 15 Vim-DBS PD |
Green/red arrow Non-lateralized Response button press |
50 % CRT | 0.034 (STN-DBS ON) 0.030 (STN-DBS OFF) |
No effect of stimulation on either false alarms or RT |
| Ballanger et al. (2009) | Off | 7 STN-DBS PD | Circle/X Non-lateralized Response button press |
100 % SRT and 60 % CRT | 0.04 (STN-DBS OFF) 0.10 (STN-DBS ON) |
STN stimulation significantly reduced RT and increased the commission error rate |
| Hershey et al. (2010) | Off | 10 STN-DBS PD | Letter/number Non-lateralized Response button press |
83 % CRT | 0.84 (STN-DBS OFF) 0.82 (dorsal STN-DBS ON) 0.78 (ventral STN-DBS ON) |
Ventral STN stimulation reduced hits and increased false alarms, i.e. decreased discriminability, but did not affect RT |
Med. status medication status (off off medication, on on medication), N number of participants, NR not reported, STN-DBS ON STN-DBS on stimulation, RT reaction time, STN-DBS OFF STN-DBS off stimulation, SRT simple reaction time, CRT choice reaction time