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Efficacies of telavancin, vancomycin, and linezolid against MRSA 33591 in the mouse neutropenic thigh model. The abscissa shows the total 24-h dosage, and the ordinate shows the titer observed in thighs. Vehicle (n = 16) and telavancin (n = 5 to 16 per dose) were administered q 24 h, whereas vancomycin (n = 5 per dose) and linezolid (n = 6 per dose) were administered q 12 h. n = 16 for the control pretreatment group. Data are expressed as means ± 1 SD (error bars).
