Table 2.

Effect of EECN on % wound contraction and epithelialization period of wound in excision wound model.

Group	% wound contraction				Epithelialization period (days)
	4th day	8th day	12th day	16th day
Group I (untreated)	4.39 ± 0.82	18.62 ± 0.69	42.62 ± 2.56	68.87 ± 0.91	19.16 ± 0.7
Group II (ointment base treated)	4.21 ± 0.19	19.48 ± 0.93	42.76 ± 1.36	71.2 ± 0.93	19.66 ± 0.66
Group III (standard)	14.55 ± 0.87 a∗∗∗, b∗∗∗	38.39 ± 0.46 a∗∗∗, b∗∗∗, c∗∗∗	67.38 ± 2.01 a∗∗∗, b∗∗∗	94.3 ± 0.43 a∗∗∗, b∗∗∗	17.33 ± 0.4 a∗∗, b∗∗
Group IV (2% w/w, ointment)	13.83 ± 1.0 a∗∗∗, b∗∗∗	31.11 ± 0.83 a∗∗∗, b∗∗∗, c∗∗	56.46 ± 0.79 a∗∗∗, b∗∗∗, c∗∗	80.21 ± 0.27 a∗∗∗, b∗∗∗, c∗∗	18.33 ± 0.22
Group V (5% w/w, ointment)	14.33 ± 0.94 a∗∗∗, b∗∗∗	34.82 ± 0.67 a∗∗∗, b∗∗∗	59.64 ± 1.18 a∗∗∗, b∗∗∗, c∗∗	93.58 ± 0.76 a∗∗∗, b∗∗∗	17.66 ± 0.7 a∗∗, b∗∗

All values are represented as mean ± SEM, n = 6 animals in each group. Data were analyzed by one-way ANOVA, followed by Tukey-Kramer Multiple Comparisons Test. a: significant difference as compared to untreated group (group I); b: significant difference as compared to ointment base treated group (group II); c: significant difference as compared to standard group (group III), and ^∗∗ P < 0.01, ^∗∗∗ P < 0.001.