Table 2.
Comparison of the concentrations of circulating biomarkers of immune activation of mothers, their children, and their respective controls.
| Mothers baseline n = 46 [Median (range)] |
Adult controls n = 20 [Median (range)] |
P value | Children baseline n = 46 [Median (range)] |
Paediatric controls n = 20 [Median (range)] |
P value | |
|---|---|---|---|---|---|---|
| sCD14 (ng/mL) |
8,068 (0.00–19,431) |
5,971 (853–8,220) |
<0.0011 | 9,741 (481–20,448) |
3,826 (0.0–21615) |
<0.0001 |
|
β2M (μg/mL) |
2.84 (0.847–6.86) |
1.360 (1.02–3.77) |
<0.0001 | 4 (1.8–7.4) |
2.135 (0.23–4) |
<0.0001 |
| hsCRP (μg/mL) |
1.8 (0.173–10.3) |
0.8 (0.173–7.5) |
0.0242 | 5 (0.2–144) |
<0.173 (<0.173–8) |
<0.0001 |
| MIG (pg/mL) |
2143 (595–19,734) |
190.4 (84.9–2,932) |
<0.0001 | 3,808 (1,058–13,818) |
3,103 (158–16,563) |
0.0779 |
| IP10 (pg/mL) |
6,866 (2,267–64,710) |
1,075 (690–12,005) |
<0.0001 | 7,171 (1,054–636,325) |
21 (1.6–1,662) |
<0.0001 |
| TGF-β1 (pg/mL) |
22,480 (52.8–33,685.5) |
10,960.7 (3,157.6–31,806.7) |
0.0093 | 12,627 (67–30,336) |
11,374 (499–19,580) |
<0.0001 |
sCD14 (soluble CD14), β2M (β2-microglobulin), hsCRP (high sensitivity CRP), MIG (monokine induced IFNγ), IP10 (IFNγ-inducible protein 10), and TGF-β1 (transforming growth factor beta 1).