TABLE 3.
Population pharmacokinetic parameter estimates for daptomycinb
| Structural model parameter | Median value (RSE [%]) | % Interindividual CV (RSE [%]) |
|---|---|---|
| CL (liter/h) for male subject with median creatinine clearance (91.2 ml/min) | 0.807 (2.9) | 30.6 (10.5) |
| Change in CL (liter/h) for each 10 ml/min that creatinine clearance differs from the median value | 0.0514 (10.9) | |
| CL (liter/h) for subject on dialysis | 0.269 (6.1) | |
| Fractional change in CL for female subject | 0.801 (4.0) | |
| Change in CL (liter/h) for each °C that temp differs from the median value (37.2°) | 0.14 (32.1) | |
| V1 (liters) | 4.80 (4.2) | 56.7 (26.8) |
| Q (liter/h) for subject with median body weight (75 kg) | 3.46 (6.3) | 65.2 (39.5) |
| Change in Q (liter/h) for each 10 kg that body weight differs from the median value | 0.593 (20.4) | |
| V2 (liters) for subject with median body weight (75 kg) | 3.13 (2.7) | 19.1 (27.4) |
| Change in V2 (liters) for each 10 kg that body weight differs from the median value | 0.458 (12.0) | |
| Fractional change in V2 for subject with infection | 1.93 (9.5) | |
| Duration of infusion (h) | 0.384 (27.3) | NEa |
a
NE, not estimated.
b
For the residual error parameter σ2add for studies that used the LC/MS/MS assay, the estimated value was 4.28, with an RSE of 23.1% and an intraindividual error SD of 2.07 μg/ml. For the parameter σ2add for studies that used the HPLC assay, the estimated value was 22.4, with an RSE of 20.3% and an intraindividual error SD of 4.73 μg/ml.