TABLE 2.
Prevalence of resistance to antimicrobial agents in clinical strains of N. gonorrhoeae recovered in central Japan from 1999 to 2002
| Strain characteristic | Prevalence (%)
|
||
|---|---|---|---|
| 1999-2000 (n = 91) | 2001 (n = 150) | 2002 (n = 221) | |
| Penicillinase producing | 1.1 | 0.7 | 0.5 |
| High-level tetracycline resistance (MIC, ≥16 μg/ml) | 2.2 | 0.7 | 0.5 |
| Chromosomally mediated resistance to penicillin (MIC, ≥2 μg/ml) | 2.2 | 59.3 | 73.3 |
| Chromosomally mediated resistance to tetracycline (MIC, ≥2 μg/ml) | 11.0 | 53.7 | 68.8 |
| Levofloxacin resistance (MIC of ≥1 μg/ml equivalent to ofloxacin MIC of ≥2 μg/ml) | 27.5 | 53.3 | 78.3 |
| Decreased susceptibility to cefixime (MIC, ≥0.5 μg/ml) | 0 | 26.0 | 30.3 |
| Decreased susceptibility to ceftriaxone (MIC, ≥0.5 μg/ml) | 0 | 0 | 0.9 |
| Spectinomycin resistance (MIC, ≥128 μg/ml) | 0 | 0.7 | 0 |