Table 3. Subgroup analysis of diagnostic indices (with 95% confidence intervals) and subsequent meta-regression on DOR.
| Subgroup | No. of studies | Sensitivity pooled | Specificity pooled | PLR pooled | NLR pooled | DOR pooled | RDOR | P Value |
|---|---|---|---|---|---|---|---|---|
| Study design | ||||||||
| Prospective | 12 | 86(82–88) | 97(91–100) | 7.3(3.7–14.2) | 0.14(0.07–0.27) | 70(29–170) | 1.29(0.18–9.12) | 0.785 |
| Retrospective | 4 | 79(72–86) | 98(88–99) | 10.8(3.3–35.5) | 0.24(0.14–0.41) | 52(13–204) | ||
| Study length | ||||||||
| <12 | 9 | 89(85–92) | 95(84–99) | 6.4(3.0–13.4) | 0.14(0.06–0.30) | 61(22–167) | 2.08(0.34–12.75) | 0.400 |
| >12 | 7 | 80(76–84) | 99(93–100) | 11.5(4.5–29.3) | 0.21(0.12–0.36) | 68(23–205) | ||
| Location | ||||||||
| USA | 8 | 85(79–89) | 97(89–100) | 7.43(3.4–16.2) | 0.19(0.12–0.33) | 56(20–161) | 115(0.22–5.98) | 0.859 |
| Others | 8 | 84(81–87) | 98(91–100) | 8.85(3.7–21.1) | 0.14(0.06–0.32) | 73(25–214) | ||
| Study center | ||||||||
| Single | 11 | 81(77–85) | 97(89–100) | 6.65(3.3–13.1) | 0.19(0.11–0.32) | 45(18–110) | 2.86(0.50–16.52) | 0.218 |
| Multiple | 5 | 90(85–93) | 98(91–100) | 13.1(4.4–38.7) | 0.12(0.05–0.27) | 136(37–501) | ||
| On–site pathol–ogist for all | ||||||||
| Yes | 8 | 88(83–92) | 96(82–100) | 5.3(2.4–11.8) | 0.16(0.06–0.38) | 42(13–132) | 3.77(0.64–22.33) | 0.132 |
| No | 8 | 82(79–86) | 98(92–100) | 12.7(5.4–29.5) | 0.17(0.09–0.29) | 87(32–233) | ||
| Needle type | ||||||||
| PreCore | 10 | 91(88–93) | 99(93–100) | 9.3(4.3–20.6) | 0.12(0.08–0.20) | 95(36–247) | 0.87(0.26–2.92) | 0.811 |
| Trucut | 4 | 62(54–69) | 97(84–100) | 6.7(2.1–21.6) | 0.43(0.32–0.57) | 18(5–71) | ||
| Flexible | 2 | 97(90–100) | 93(66–100) | 6.6(1.9–23.7) | 0.05(0.02–0.16) | 235(24–2295) | ||
| Ratio of head and uncinate | ||||||||
| >0.6 | 6 | 90(86–94) | 96(87–100) | 8.7(3.6–20.6) | 0.11(0.05–0.23) | 125(38–411) | 0.62(0.08–4.61) | 0.599 |
| <0.6 | 6 | 86(82–90) | 98(89–100) | 9.2(3.4–24.9) | 0.16(0.06–0.40) | 62(14–272) | ||
| No. of patinets | ||||||||
| >50 | 10 | 85(82-88) | 98(93–100) | 11.9(5.6–25.8) | 0.14(0.08–0.24) | 98(40–242) | 0.19(0.03–1.14) | 0.067 |
| <50 | 6 | 82(75–88) | 94(73–100) | 4.7(1.9–11.4) | 0.22(0.09–0.55) | 25(7–96) |
PLR, positive likelihood ratio; NLR, Negative likelihood ratio; DOR, diagnostic odds ratio; RDOR, relative diagnostic odds ratio; CI, confidence intervals.