TABLE 1.
Pharmacokinetic parameters of ITC, OH-ITC, and HP-β-CD before dialysis, after dialysis, interdialysis, and intradialysisa
| Compound and parameter | BD | AD | ID | HD |
|---|---|---|---|---|
| ITC | ||||
| Cmax (ng/ml) | 1,980 ± 659 | 1,889 ± 1,237 | NAb | NA |
| V (liters/kg) | 17.5 ± 11.6 | 9.4 ± 2.8 | NA | NA |
| AUC0-∞ (ng · h/ml) | 8,047 ± 7,640 | 6,293 ± 3,707 | NA | NA |
| ke (h−1) | 0.07 ± 0.06 | 0.06 ± 0.01 | 0.07 ± 0.04 | 0.14 ± 0.09 |
| t1/2 (h) | 19.7 ± 16.2 | 12.0 ± 2.0 | 14.6 ± 8.5 | 14.7 ± 24.1 |
| OH-ITC | ||||
| Cmax (ng/ml) | 269 ± 96 | 408 ± 181 | NA | NA |
| AUC0-∞ (ng · h/ml) | 13,236 ± 21,111 | 9,523 ± 6,886 | NA | NA |
| ke (h−1) | 0.07 ± 0.05 | 0.06 ± 0.04 | 0.06 ± 0.03 | 0.07 ± 0.05 |
| t1/2 (h) | 14.5 ± 9.8 | 19.7 ± 15.9 | 15.6 ± 6.9 | 17.0 ± 15.0 |
| HP-β-CD | ||||
| Cmax (ng/ml) | 662 ± 171 | 773 ± 265 | NA | NA |
| V (liters/kg) | 0.21 ± 0.03 | 0.30 ± 0.09 | NA | NA |
| AUC0-∞ (ng · h/ml)c,d | 5,485 ± 2,202 | 30,282 ± 12,098 | 21,638 ± 8228e | 817 ± 262f |
| ke (h−1)d | NA | NA | 0.02 ± 0.01 | 0.32 ± 0.18 |
| t1/2 (h)d | NA | NA | 33.3 ± 12.0 | 2.9 ± 1.5 |
| CLg (liters/h)d | NA | NA | 0.41 ± 0.14 | 2.25 ± 1.46 |
a
Values are reported as the mean ± the standard deviation. BD, dose administered before dialysis; AD, dose administered after dialysis; ID, interdialysis period (between dialysis sessions); HD, intradialysis period (during dialysis sessions).
b
NA, not applicable.
c
AD versus BD, P < 0.05.
d
HD versus ID, P < 0.05.
e
AUCid.
f
AUChd.
g
CL, clearance.