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. 2016 Mar 10;6:22847. doi: 10.1038/srep22847

Figure 1. Schematic presentation of Cas9-sgRNA delivery system for down regulation of MDR1.

Figure 1

Cas9-sgRNA system was introduced into the multidrug resistant cells (MCF-7/ADR) via transfection of the cells with the plasmid for expression of Cas9-sgRNA and intracellular delivery of the Cas9-sgRNA ribonucleoprotein complex using either a PTD peptide or Lipofectamine.