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. 2016 Mar 10;6:22847. doi: 10.1038/srep22847

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Fluorescence microscopic images showing DOX accumulation in MCF-7 (drug-sensitive) and MCF-7/ADR (drug-resistant) cells. (B) Fluorescence microscopic images showing DOX accumulation in MCF-7/ADR cells treated with Cas9-sgRNA (scale bar: 20 μm). (C) Flow cytometric analysis of intracellular DOX accumulation. The data represent the mean ± s.d. (n = 12). ****P ≤ 0.0001 vs. untreated MCF-7/ADR cells.