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. 2016 Mar 10;6:22847. doi: 10.1038/srep22847

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Cell viability of MCF-7/ADR cells at various concentrations of DOX was examined after treatment with Cas9-sgRNA using the plasmid (blue bars), LF3K (green bars) and TAT (yellow bars), and compared with that of untreated MCF-7 (white bars) and MCF-7/ADR cells (red bars). The data represent the mean ± s.d. (n = 7). ns P > 0.05, ***P ≤ 0.001, ****P ≤ 0.0001 vs. untreated MCF-7 cells.