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. 2016 Mar 10;6:22932. doi: 10.1038/srep22932

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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We identified a total of 44 enriched DEmiRNAs for which the miRNA targets defined by multimiR were significantly enriched (according to a hypergeometric test or its generalization). The 44 DEmiRNAs were inversely correlated with a total of 351 unique target DEGs. The network is displayed graphically as nodes (genes and miRNAs) and edges (biological relationships). The edge colour intensity indicates the expression level (log2) of the association: red = over-expression at T1 and green = under-expression at T1. The node shape indicates whether the node is a transcription regulator (triangles), growth factor (round rectangles), peptidase (diamonds), phosphatase (hexagons), transmembrane receptor (parallelograms), transporter (octagons), a miRNA (squares) or other type of genes (ellipses).